Subject(s)
COVID-19 , Pediatrics , COVID-19/complications , Child , Humans , Incidence , SARS-CoV-2 , Systemic Inflammatory Response Syndrome , VaccinationABSTRACT
BACKGROUND: As part of the fight against SARS CoV2 infection, vaccination program for health workers at Giannina Gaslini pediatric hospital (IGG) in Genoa, Italy, started on December 2020. We evaluated the anti-Spike protein response in healthcare workers after a complete vaccination scheme of 2 doses spaced by 3 weeks. METHODS: Immunoglobulin class G (IgG) against SARS-CoV-2 spike RBD were detected by means of a chemiluminescence immunoassay for quantitative IgG antibodies using Maglumi SARS-CoV-2-S-RBD IgG kit during the 3rd week after vaccination completion. RESULTS: IgG anti SARS-CoV-2 spike protein were detected in 99.88% of 1765 healthcare workers 3 weeks after 2nd dose of BNT162b2. Higher median IgG values were observed in younger subjects (807 UA/mL in under 30 vs 429 UA/mL in over 60; p < 0.001) and those with previous COVID-19 (1284 vs 574 UA/mL; p < 0.001). CONCLUSION: BNT162b2 is effective in inducing anti SARS-CoV-2 antibodies even in real-life setting. The higher antibody title observed in workers with a previous documented SARS CoV2 infection confirms the possibility to carry out only one dose of BNT162b2 in a context of vaccines shortage.
Subject(s)
COVID-19 Vaccines/immunology , COVID-19 , Spike Glycoprotein, Coronavirus/immunology , BNT162 Vaccine , COVID-19/prevention & control , Health Personnel , Humans , Italy , SARS-CoV-2 , Spike Glycoprotein, Coronavirus/geneticsABSTRACT
The Covid-19 pandemic has been the most defining event of our era. The world of healthcare has experienced first-hand the dramatic situation of treating patients in the face of the dangers of contagion and limited resources. Difficult choices have everywhere been made alongside ethical reflection. Now that, at least in our part of the world, viral infection seems to be broadly on the decline, there is an urgent need for fresh, anthropological, ethical reflection. It is important to avoid being unprepared in the event of further occasions, but above all, to now think in global terms. This is because the pandemic has forced us to recognise the urgency of building alliance in healthcare and a balanced relationship with the environment.